Both can run games at a higher internal resolution (sharper 3D objects), and can open roms inside an archive (zip, rar, 7z). Has similar DS game compatibility as DeSmuME. In terms of being user-friendly, options in melonDS are more simplified. Unlike DeSmuME, melonDS can use wifi, and has some DSi support.
Nintendo DS Emulators Emulation General WikiĦ hours ago 1.